It takes T to tango

Neuron. 2001 Jul 19;31(1):3-4. doi: 10.1016/s0896-6273(01)00349-x.

Abstract

Of three recently cloned T-type voltage-gated calcium channels, alpha(1g) is most likely responsible for burst firing in thalamic relay cells. These neurons burst during various thalamocortical oscillations including absence seizures. In this issue of Neuron, Kim et al. inactivated alpha(1g), and resultant mice were deficient in relay cell bursting and resistant to GABA(B) receptor-dependent absence seizures, suggesting roles for alpha(1g) and relay cell bursting in absences.

Publication types

  • Comment

MeSH terms

  • Animals
  • Calcium Channels, T-Type / physiology*
  • Cerebral Cortex / physiology
  • Cerebral Cortex / physiopathology
  • Child
  • Electroencephalography
  • Epilepsy, Absence / physiopathology
  • Humans
  • Mice
  • Neurons / physiology*
  • Receptors, GABA-B / physiology
  • Seizures / physiopathology
  • Thalamus / physiology
  • Thalamus / physiopathology

Substances

  • Calcium Channels, T-Type
  • Receptors, GABA-B