Antigen presentation to CD8+ T cells: cross-priming in infectious diseases

Curr Opin Immunol. 2001 Aug;13(4):437-41. doi: 10.1016/s0952-7915(00)00238-7.


Recent studies indicate that, in most types of infections, antigen presentation by 'professional' bone-marrow-derived cells is essential for priming pathogen-specific CD8+ T cells. This is true even in the absence of direct infection of these cells, which indicates that cross-priming is an essential component of the immune response against pathogens.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation*
  • Antigen-Presenting Cells / immunology
  • Apoptosis / immunology
  • CD8-Positive T-Lymphocytes / immunology*
  • Communicable Diseases / immunology*
  • Communicable Diseases / pathology
  • Dendritic Cells / immunology
  • Humans
  • Necrosis