Expression and function of NK cell receptors in CD8+ T cells

Curr Opin Immunol. 2001 Aug;13(4):465-70. doi: 10.1016/s0952-7915(00)00242-9.

Abstract

A wide variety of inhibitory and stimulatory NK cell receptors are expressed by some CD8+ cytotoxic T lymphocytes in mice and humans. Recent data address the induction of these receptors on activated or memory CD8+ T cells and have led to hypotheses addressing their function in the CD8+ T cell response.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigens, Ly*
  • CD8-Positive T-Lymphocytes / immunology*
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology
  • Cytotoxicity, Immunologic
  • Gene Expression
  • Histocompatibility Antigens Class I / metabolism
  • Humans
  • Infections / immunology
  • Killer Cells, Natural / immunology*
  • Lectins, C-Type
  • Ligands
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology
  • Mice
  • Receptors, Immunologic / genetics*
  • Receptors, Immunologic / immunology
  • Receptors, Immunologic / physiology*
  • Receptors, KIR
  • Receptors, NK Cell Lectin-Like
  • Receptors, Natural Killer Cell

Substances

  • Antigens, Ly
  • Carrier Proteins
  • Histocompatibility Antigens Class I
  • Lectins, C-Type
  • Ligands
  • Membrane Proteins
  • Receptors, Immunologic
  • Receptors, KIR
  • Receptors, NK Cell Lectin-Like
  • Receptors, Natural Killer Cell