A study of 13 patients with gastric tube in place after esophageal resection: use of omeprazole to decrease gastric acidity and volume

J Clin Anesth. 2001 Aug;13(5):370-3. doi: 10.1016/s0952-8180(01)00289-6.


Study objective: To investigate whether oral omeprazole 20 mg decreases the risk of aspiration pneumonia in patients with gastric tube reconstruction.

Design: Consecutive study.

Setting: Operation room of cancer center.

Patients: Thirteen patients with gastric tube reconstruction for esophageal cancer.

Interventions: Oral omeprazole 20 mg was given the night before surgery. A rapid-sequence induction with cricoid pressure was employed for induction of anesthesia. After tracheal intubation, a nasogastric catheter was inserted into the gastric tube and the contents were aspirated.

Measurements and main results: The pH and volume of the gastric contents were measured. The pH and volume of the gastric tube contents were 4.5 +/- 1.6 (range from 2.5 to 7.0) and 9.5 +/- 10.2 mL (range from 0 to 30 mL), respectively. Food residue was recognized in nine patients. There was no patient with a pH below 2.5 and a volume of 25 mL or greater.

Conclusions: Omeprazole 20 mg decreased the acidity and volume of the gastric tube contents and reduced the risk of aspiration pneumonia in patients with a gastric tube in place.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Anti-Ulcer Agents / therapeutic use*
  • Esophagus / surgery*
  • Female
  • Gastric Acid / chemistry*
  • Humans
  • Hydrogen-Ion Concentration
  • Intubation, Gastrointestinal
  • Male
  • Middle Aged
  • Omeprazole / therapeutic use*
  • Pneumonia, Aspiration / prevention & control*
  • Stomach / drug effects*


  • Anti-Ulcer Agents
  • Omeprazole