Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2001 Aug 10;293(5532):1164-6.
doi: 10.1126/science.1060937.

Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease

Affiliations
Free article
Clinical Trial

Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease

R de la Fuente-Fernández et al. Science. .
Free article

Abstract

The power of placebos has long been recognized for improving numerous medical conditions such as Parkinson's disease (PD). Little is known, however, about the mechanism underlying the placebo effect. Using the ability of endogenous dopamine to compete for [11C]raclopride binding as measured by positron emission tomography, we provide in vivo evidence for substantial release of endogenous dopamine in the striatum of PD patients in response to placebo. Our findings indicate that the placebo effect in PD is powerful and is mediated through activation of the damaged nigrostriatal dopamine system.

Similar articles

See all similar articles

Cited by 178 articles

See all "Cited by" articles

Publication types

MeSH terms

Feedback