Bronchodilator responsiveness in normal infants and young children

Am J Respir Crit Care Med. 2001 Aug 1;164(3):447-54. doi: 10.1164/ajrccm.164.3.2005080.


Several studies have demonstrated that normal infants exhibit bronchoconstriction after inhalation of nonspecific agonists and that the induced airway narrowing can be reversed by the inhalation of a beta-agonist. However, there are very limited data on baseline airway tone and the airway response to a beta-agonist in this subject population. The purpose of our study was to evaluate in normal infants baseline airway responsiveness to the inhaled beta-agonist, albuterol, using changes in maximal expiratory flows. Forty-one healthy infant volunteers with no history of respiratory disease or recurrent wheezing (ages 5.4 to 141.4 wk) were studied. Maximal expiratory flow- volume curves were obtained at baseline and 10 min after inhalation of albuterol (n = 28) or placebo (n = 13) using a metered-dose inhaler with a spacer. The mean percent change was significantly greater (p < 0.05) in the albuterol versus placebo group for FEV(0.5) (2.2% versus -1.5%), FEF(75%) (10.6% versus -3.1%), and FEF(85%) (12.9% versus 0.5%). Six of 28 albuterol-treated infants demonstrated increases in FEF(75%) greater than two standard deviations from the mean change in FEF(75%) seen in the placebo group. These infants were younger and more frequently exposed to maternal smoking during pregnancy. We conclude that normal healthy infants have overall levels of baseline airway tone that are similar to that reported in adults and older children; however, among the infants we evaluated the response to an inhaled bronchodilator was greatest in the youngest infants and in those exposed to tobacco smoking.

Keywords: airway responsiveness; asthma; tobacco smoke; infant pulmonary function; bronchodilator

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Inhalation
  • Adult
  • Airway Resistance / physiology*
  • Albuterol / pharmacology*
  • Bronchodilator Agents / pharmacology*
  • Female
  • Forced Expiratory Flow Rates
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Pregnancy
  • Tobacco Smoke Pollution / adverse effects*


  • Bronchodilator Agents
  • Tobacco Smoke Pollution
  • Albuterol