Abstract
Burned Pseudomonas aeruginosa-infected mice immunized against PcrV, a type III virulence system translocating protein, showed significantly enhanced survival compared to controls. Survival was non-O serotype specific and correlated with a reduced systemic microbial load. Infection with a high-level toxin A-producing strain required supplemental antitoxin treatment to enhance survival.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Bacterial / blood
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Antigens, Bacterial / administration & dosage
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Antigens, Bacterial / immunology*
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Antitoxins / administration & dosage
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Antitoxins / immunology
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Bacterial Toxins / administration & dosage
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Bacterial Toxins / immunology*
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Bacterial Vaccines / administration & dosage
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Bacterial Vaccines / immunology
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Burns / complications*
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Disease Models, Animal
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Humans
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Mice
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Pore Forming Cytotoxic Proteins
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Pseudomonas Infections / immunology*
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Pseudomonas Infections / mortality
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Pseudomonas Infections / prevention & control
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Pseudomonas Infections / therapy
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Pseudomonas aeruginosa / immunology*
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Vaccination
Substances
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Antibodies, Bacterial
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Antigens, Bacterial
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Antitoxins
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Bacterial Toxins
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Bacterial Vaccines
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Pore Forming Cytotoxic Proteins
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antigen V, Pseudomonas
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toxin A (Pseudomonas)