Abstract
Estradiol-17beta, estradiol-benzoate, estradiol-valerianate, and estradiol-undecylate were injected intravenously and intramuscularly to postmenopausal woman and to female castrates. Equal doses were used corresponding to 20 mg of free estradiol-17beta. Estradiol-17beta, estrone, FSH and LH were measured in serum by radioimmunoassay before and after application of the hormone and the estradiol esters. Thus the depot effect of the different esters could be compared.
MeSH terms
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Adult
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Benzoates / pharmacology
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Castration
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Dose-Response Relationship, Drug
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Esters
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Estradiol / analogs & derivatives
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Estradiol / blood*
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Estrone / blood*
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Female
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Follicle Stimulating Hormone / blood*
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Humans
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Hysterectomy
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Infertility, Female / blood
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Injections, Intramuscular
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Injections, Intravenous
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Luteinizing Hormone / blood*
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Menopause
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Middle Aged
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Ovary / surgery
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Radioimmunoassay
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Structure-Activity Relationship
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Undecylenic Acids
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Valerates / pharmacology
Substances
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Benzoates
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Esters
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Undecylenic Acids
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Valerates
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Estrone
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Estradiol
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Luteinizing Hormone
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Follicle Stimulating Hormone