Radioguided-surgery of early breast lesions

Anticancer Res. May-Jun 2001;21(3C):2091-7.


Background: Radioguided-surgery has been recently proposed in patients with clinically occult breast lesions. This study aimed to evaluate the feasibility of correctly locating and eradicating, by a single intralesional injection of a radiotracer, any breast lesion and, in the case of malignancy, to perform simultaneous sentinel lymph node (SLN) biopsy procedure.

Patients and methods: Sixty-three women with early breast lesions were enrolled: 42 were invasive carcinomas, 16 in situ ductal carcinomas (DCIS) and 5 fibroadenomas.

Results: Scintigraphic images clearly identified the lesions in all patients while SLN/s were evident in 88% of them. At surgery all the breast lesions were easily radiolocalized and eradicated with minimum surgical trauma and, for those patients with invasive carcinomas, the SLN technique was performed in 86% of them. No skip metastases were found.

Conclusion: A single intralesional administration of radiotracer is an easy and reliable procedure to simultaneously locate and remove both the non-palpable breast lesion and the SLN when primary malignancy was intraoperatively confirmed.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Breast Neoplasms / diagnostic imaging*
  • Breast Neoplasms / surgery*
  • Female
  • Humans
  • Injections, Intralesional
  • Lymph Nodes / surgery
  • Mastectomy, Segmental / methods
  • Middle Aged
  • Radionuclide Imaging
  • Radiopharmaceuticals / therapeutic use*
  • Sentinel Lymph Node Biopsy
  • Technetium Tc 99m Aggregated Albumin / therapeutic use*


  • Radiopharmaceuticals
  • Technetium Tc 99m Aggregated Albumin
  • technetium Tc 99m nanocolloid