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. 2001 Aug;86(2):163-71.
doi: 10.1079/bjn2001391.

Learning Behaviour and Cerebral Protein Kinase C, Antioxidant Status, Lipid Composition in Senescence-Accelerated Mouse: Influence of a Phosphatidylcholine-Vitamin B12 Diet

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Learning Behaviour and Cerebral Protein Kinase C, Antioxidant Status, Lipid Composition in Senescence-Accelerated Mouse: Influence of a Phosphatidylcholine-Vitamin B12 Diet

M C Hung et al. Br J Nutr. .

Abstract

Our objective was to determine whether dietary supplementation with phosphatidylcholine (PC) plus vitamin B12 could afford beneficial effects on biochemical and biophysical events in the brain of senescence-accelerated mouse (SAM) substrain SAMP8. We measured learning behaviour, hippocampal protein kinase C (PKC) activity, cerebral antioxidant status, phospholipid composition and fatty acid composition in 6-month-old SAMP8 and in age-matched controls (SAM substrain SAMR1). In comparison with SAMR1, SAMP8 showed a significant elevation in total grading score of senescence and a significant decline in acquisition SAMP8 had a lower hippocampal PKC activity and cerebral PKC-beta mRNA abundance than SAMR1. SAMP8 had increased cerebral lipid peroxide levels and proportion of sphingomyelin, and a lower proportion of 20 : 4n-6 and 22 : 6n-3 in cerebral phosphtidylethanolamine than SAMR1. SAMP8 fed the PC combined with vitamin B12 diet had an increased PKC activity and a higher proportion of 22 : 6n-3 than SAMP8 fed the control diet. These results indicate the potential benefit of PC combined with vitamin B12 as a dietary supplement.

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