Frequency of C3435T polymorphism of MDR1 gene in African people

Lancet. 2001 Aug 4;358(9279):383-4. doi: 10.1016/S0140-6736(01)05579-9.


The variability of P-glycoprotein expression between individuals is linked to a C3435T polymorphism of the human MDR1 gene. Concentration of P-glycoprotein in intestinal epithelial cells and in a subset of lymphoid cells is substantially lower in people with the T/T genotype than those with the C/C genotype. We compared allele frequencies of the C3435T polymorphism in random samples of west African, African American, white, and Japanese people. We recorded a significantly higher frequency of the C/C genotype in West Africans and African Americans (142 of 172 [83%] and 25 of 41 [61%], respectively), than in white people (139 of 537 [26%]) (p<0.0001). These findings could affect use of drugs that are P-glycoprotein substrates (such as HIV-1 protease inhibitors and ciclosporin) in African populations.

Publication types

  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics*
  • Asian People
  • Black People*
  • Gene Frequency*
  • Genes, MDR / genetics*
  • Genotype
  • Ghana
  • Humans
  • Polymorphism, Genetic
  • Random Allocation
  • White People


  • ATP Binding Cassette Transporter, Subfamily B, Member 1