The glucose-regulated proteins: stress induction and clinical applications

Trends Biochem Sci. 2001 Aug;26(8):504-10. doi: 10.1016/s0968-0004(01)01908-9.


A protective mechanism used by cells to adapt to stress of the endoplasmic reticulum (ER) is the induction of members of the glucose-regulated protein (Grp) family. The induction of mammalian Grp proteins in response to ER stress involves a complex network of regulators and novel mechanisms. The elucidation of Grp function and regulation opens up new therapeutic approaches to diseases associated with ER stress and cancer.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Genetic Therapy
  • HSP70 Heat-Shock Proteins / genetics*
  • HSP70 Heat-Shock Proteins / metabolism
  • Humans
  • Immunotherapy
  • Membrane Proteins / genetics*
  • Membrane Proteins / metabolism
  • Neoplasms / metabolism
  • Neoplasms / therapy
  • Oxidative Stress*
  • Promoter Regions, Genetic
  • Transcription, Genetic


  • HSP70 Heat-Shock Proteins
  • Membrane Proteins
  • glucose-regulated proteins