Aspirin Dosages for the Dog

J Am Vet Med Assoc. 1975 Jul 1;167(1):63-4.

Abstract

Aspirin dosages calculated from published pharmacokinetic data were tested in 3 male and 3 female Basset Hounds. Emesis occurred frequently after dosing at the rate of 50 mg/kg of body weight, a dosage that would be required for a convenient 12-hour dosing interval. A dosage of 25 mg/kg every 12 hours avoided emesis but did not maintain serum salicylate concentrations within the desired range of 10 to 30 mg/100 ml. A dosage of 25 mg/kg every 8 hours resulted in serum salicylate concentrations varying from 12.5 to 17.8 mg/100 ml. It was concluded that a maintenance dosage of 25 to 35 mg/kg every 8 hours in optimal for the dog, based on extrapolation of data obtained in man.

MeSH terms

  • Administration, Oral
  • Animals
  • Aspirin / administration & dosage*
  • Aspirin / toxicity
  • Dog Diseases / chemically induced
  • Dogs / blood*
  • Female
  • Male
  • Salicylates / blood
  • Time Factors
  • Vomiting / chemically induced
  • Vomiting / veterinary

Substances

  • Salicylates
  • Aspirin