To be or not to be: a question of B-Raf?

Trends Neurosci. 2001 Sep;24(9):498-500. doi: 10.1016/s0166-2236(00)01889-0.

Abstract

A recent study has identified the B-Raf gene as essential for the survival of explanted sensory and motor neurons in culture in response to neurotrophic factors. This finding sheds new light on the control of neuronal development and poses new questions with regard to Raf-isozyme-specific functions.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Survival / physiology
  • Cells, Cultured / enzymology
  • Escherichia coli Proteins*
  • Humans
  • Membrane Transport Proteins / biosynthesis*
  • Membrane Transport Proteins / genetics
  • Motor Neurons / cytology
  • Motor Neurons / enzymology*
  • Neurons, Afferent / cytology
  • Neurons, Afferent / enzymology*
  • Proto-Oncogene Proteins c-raf / physiology*

Substances

  • Escherichia coli Proteins
  • Membrane Transport Proteins
  • raffinose permease, E coli
  • Proto-Oncogene Proteins c-raf