Neurophysiological effects of an extract of Eschscholzia californica Cham. (Papaveraceae)

Phytother Res. 2001 Aug;15(5):377-81. doi: 10.1002/ptr.884.


An aqueous alcohol extract of Eschscholzia californica (Ec) has been evaluated for benzodiazepine, neuroleptic, antidepressant, antihistaminic and analgesic properties, in order to complete the study of the sedative and anxiolytic effects previously demonstrated. The plant extract did not protect mice against the convulsant effects of pentylenetetrazol, and did not cause muscle relaxant effects but appeared to possess an affinity for the benzodiazepine receptor: thus, flumazenil, an antagonist of these receptors, suppressed the sedative and anxiolytic effects of the extract. The Ec extract induced peripheral analgesic effects in mice but did not possess antidepressant, neuroleptic or antihistaminic effects.

MeSH terms

  • Acetic Acid
  • Analgesics, Non-Narcotic / administration & dosage
  • Analgesics, Non-Narcotic / pharmacology*
  • Analgesics, Non-Narcotic / therapeutic use
  • Animals
  • Anti-Anxiety Agents / administration & dosage
  • Anti-Anxiety Agents / pharmacology*
  • Behavior, Animal / drug effects*
  • Dose-Response Relationship, Drug
  • Flumazenil
  • Guinea Pigs
  • Ileum / drug effects
  • Magnoliopsida*
  • Male
  • Mice
  • Pain / chemically induced
  • Pain / prevention & control*
  • Pain Measurement / drug effects
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plants, Medicinal*
  • Rats


  • Analgesics, Non-Narcotic
  • Anti-Anxiety Agents
  • Plant Extracts
  • Flumazenil
  • Acetic Acid