Impact of certain flavonoids on lipid profiles--potential action of Garcinia cambogia flavonoids

Phytother Res. 2001 Aug;15(5):395-400. doi: 10.1002/ptr.725.

Abstract

Flavonoids from Cocos nucifera, Myristica fragrance, Saraka asoka and Garcinia cambogia exerted hypolipidaemic activity in rats. Lipid lowering activity was maximum in rats administered flavonoids (10 mg/kg BW/day) from Garcinia cambogia. A dose response study revealed biphasic activity. Higher doses were less effective in reducing lipid levels in serum and tissues, although devoid of toxic effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cholesterol / blood
  • Cholesterol / metabolism*
  • Dose-Response Relationship, Drug
  • Flavonoids / administration & dosage
  • Flavonoids / pharmacology*
  • Flavonoids / therapeutic use
  • Hyperlipidemias / prevention & control*
  • Hypolipidemic Agents / administration & dosage
  • Hypolipidemic Agents / pharmacology*
  • Hypolipidemic Agents / therapeutic use
  • Male
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plants, Medicinal*
  • Rats
  • Rats, Sprague-Dawley
  • Rosales*
  • Triglycerides / blood
  • Triglycerides / metabolism*

Substances

  • Flavonoids
  • Hypolipidemic Agents
  • Plant Extracts
  • Triglycerides
  • Cholesterol