Evaluation of the antidiabetic action of Mangifera indica in mice

Phytother Res. 2001 Aug;15(5):456-8. doi: 10.1002/ptr.859.


The leaves of Mangifera indica were assessed for antidiabetic properties using normoglycaemic, glucose-induced hyperglycaemia and streptozotocin (STZ) induced diabetic mice. The aqueous extract produced a reduction of blood glucose level in normoglycaemic and glucose-induced hyperglycaemia, but did not have any effect on streptozotocin-induced diabetic mice. The hypoglycaemic effect of the aqueous extract was compared with that of an oral dose of chlorpropamide under the same conditions. The results of this study indicate that the aqueous extract of the leaves of Mangifera indica possess hypoglycaemic activity.

MeSH terms

  • Animals
  • Blood Glucose / drug effects*
  • Diabetes Mellitus / chemically induced
  • Diabetes Mellitus / prevention & control*
  • Female
  • Glucose
  • Hypoglycemic Agents / pharmacology*
  • Hypoglycemic Agents / therapeutic use
  • Male
  • Mice
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plant Leaves
  • Plants, Medicinal*
  • Rosales*
  • Streptozocin


  • Blood Glucose
  • Hypoglycemic Agents
  • Plant Extracts
  • Streptozocin
  • Glucose