Cholestatic hepatitis induced by gold

Rheumatol Rehabil. 1979 Aug;18(3):174-6. doi: 10.1093/rheumatology/18.3.174.

Abstract

A patient with rheumatoid arthritis developed an acute intrahepatic cholestasis after 100 mg of sodium aurothiomalate. Hepatotoxicity in rheumatoid arthritis is well described following a variety of anti-inflammatory preparations but is now a rare complication of gold therapy and the literature on the subject is reviewed.

Publication types

  • Case Reports

MeSH terms

  • Arthritis, Rheumatoid / drug therapy
  • Biopsy
  • Chemical and Drug Induced Liver Injury / etiology*
  • Chemical and Drug Induced Liver Injury / pathology
  • Cholestasis, Intrahepatic / chemically induced*
  • Cholestasis, Intrahepatic / pathology
  • Gold Sodium Thiomalate / adverse effects*
  • Gold Sodium Thiomalate / therapeutic use
  • Humans
  • Liver / pathology
  • Male
  • Middle Aged

Substances

  • Gold Sodium Thiomalate