Study of antiangiogenic agents with possible therapeutic applications in neoplastic disorders and macular degeneration

J L Ambrus; C A Toumbis; C P Karakousis; M Kulaylat; S Akhter; L Plavsic

Study of antiangiogenic agents with possible therapeutic applications in neoplastic disorders and macular degeneration

J Med. 2000;31(5-6):278-82.

Authors

J L Ambrus¹, C A Toumbis, C P Karakousis, M Kulaylat, S Akhter, L Plavsic

Affiliation

¹ Department of Internal Medicine, State University of NY at Buffalo Medical School-Kaleida Health Systems, 14203, USA.

PMID: 11508321

Abstract

Using a previously developed method (Ambrus, et al., 1991), we found that pentoxifylline and thalidomide potentiate each others antiangiogenic effect induced by human malignant melanoma cells in the cornea of Macaca arctoides monkeys.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angiogenesis Inhibitors / pharmacology*
Angiogenesis Inhibitors / therapeutic use
Animals
Cells, Cultured
Cornea / drug effects*
Corneal Neovascularization / drug therapy*
Corneal Neovascularization / pathology
Drug Combinations
Enzyme Inhibitors / pharmacology
Humans
Keratinocytes
Macaca
Macular Degeneration / drug therapy
Melanoma / pathology*
Pentoxifylline / pharmacology*
Thalidomide / pharmacology*

Substances

Angiogenesis Inhibitors
Drug Combinations
Enzyme Inhibitors
Thalidomide
Pentoxifylline