Characteristics of depressive behavior induced by feeding thiamine-deficient diet in mice

Life Sci. 2001 Jul 27;69(10):1181-91. doi: 10.1016/s0024-3205(01)01206-1.

Abstract

We produced thiamine-deficient (TD) mice by TD diet treatment. The growth curve of mice on TD feeding was sharply increased until on the 10th day and subsequently the body weight gradually decreased. The mortality rate in mice was about 67% on the 30th day after the start of TD feeding. We performed the forced swimming test on the 10th and 20th day after the start of TD feeding. The duration of immobility in the forced swimming test was increased on the 20th day of TD feeding. Locomotor activity and motor co-ordination between the pair-fed control group and TD group on the 20th day of TD feeding were not significantly changed. Only a single injection of thiamine HCI (50 mg/kg, s.c.) on the 10th day after the start of a TD diet shortened the increased duration of immobility in the forced swimming test on the 20th day after the start of TD feeding. Whereas these reversal effects of thiamine treatment on the 20th day were not found when the treatment was given on the 19th day after the start of a TD diet. On the 20th day after the start of TD feeding, the increased duration of immobility time induced by TD was shortened by chronic administration of the tricyclic antidepressant imipramine (10 mg/kg, i.p.). These results suggested that behavioral changes in the forced swimming test might be involved in the degeneration of serotonergic and noradrenergic neurons.

MeSH terms

  • Animals
  • Antidepressive Agents, Tricyclic / therapeutic use
  • Behavior, Animal / drug effects
  • Behavior, Animal / physiology*
  • Body Weight / drug effects
  • Body Weight / physiology
  • Depression / drug therapy
  • Depression / physiopathology
  • Depression / psychology*
  • Diet
  • Disease Models, Animal
  • Imipramine / administration & dosage
  • Imipramine / therapeutic use
  • Injections, Intraperitoneal
  • Injections, Subcutaneous
  • Longevity / drug effects
  • Longevity / physiology
  • Male
  • Mice
  • Mice, Inbred Strains
  • Motor Activity / drug effects
  • Motor Activity / physiology
  • Swimming / physiology
  • Thiamine / administration & dosage
  • Thiamine / therapeutic use
  • Thiamine Deficiency / drug therapy
  • Thiamine Deficiency / physiopathology
  • Thiamine Deficiency / psychology*
  • Time Factors

Substances

  • Antidepressive Agents, Tricyclic
  • Imipramine
  • Thiamine