Use of montelukast as steroid-sparing agent for recurrent eosinophilic gastroenteritis

Dig Dis Sci. 2001 Aug;46(8):1787-90. doi: 10.1023/a:1010682310928.


Patients with eosinophilic gastroenteritis generally respond well to corticosteroids but relapses are common. Patients with relapsing disease are usually placed on long-term low-dose prednisone or immunosuppressive therapy. Here we reported on a patient with severe steroid-dependent eosinophilic gastroenteritis who was able to successfully taper off steroids and maintain remission after starting montelukast, a leukotriene receptor antagonist. To our knowledge, this is the first use of montelukast as a steroid sparing agent for eosinophilic gastroenteritis.

Publication types

  • Case Reports

MeSH terms

  • Acetates / therapeutic use*
  • Adult
  • Cyclopropanes
  • Eosinophilia / drug therapy*
  • Gastroenteritis / drug therapy*
  • Glucocorticoids / therapeutic use
  • Humans
  • Leukotriene Antagonists / therapeutic use*
  • Male
  • Prednisone / therapeutic use
  • Quinolines / therapeutic use*
  • Recurrence
  • Sulfides


  • Acetates
  • Cyclopropanes
  • Glucocorticoids
  • Leukotriene Antagonists
  • Quinolines
  • Sulfides
  • montelukast
  • Prednisone