Promoter characterization and expression of the gene coding for the human GM2 activator protein

Biosci Rep. 2001 Feb;21(1):55-62. doi: 10.1023/a:1010434101610.


Genomic clones of the human GM2 activator protein have been isolated and analyzed. The 5' region of the gene demonstrated promoter activity as ascertained by its ability to drive luciferase gene expression in transfected COS cells. This sequence contains GC rich region and several putative promoter elements were present, including Sp1, AP2, cAMP-responsive element, and B-cell-specific activating protein. Analysis of tissue distribution of the GM2 activator protein gene revealed tissue-specific variations in transcript levels. Placenta, bone marrow, mammary gland, bladder, lymph node, and spleen had the highest mRNA levels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 5' Flanking Region / physiology*
  • Base Sequence / genetics
  • Brain / metabolism
  • Cloning, Molecular
  • Exons / genetics
  • G(M2) Activator Protein
  • G(M2) Ganglioside / genetics
  • G(M2) Ganglioside / metabolism*
  • Gangliosidoses, GM2 / genetics*
  • Gangliosidoses, GM2 / metabolism
  • Gangliosidoses, GM2 / physiopathology
  • Gene Expression Regulation / physiology*
  • Genomic Library
  • Humans
  • Introns / genetics
  • Molecular Sequence Data
  • Promoter Regions, Genetic / physiology*
  • Proteins / genetics*
  • RNA, Messenger / metabolism
  • Transcription, Genetic / physiology*
  • Viscera / metabolism


  • G(M2) Activator Protein
  • Proteins
  • RNA, Messenger
  • G(M2) Ganglioside

Associated data

  • GENBANK/AF173832