Elevated serum levels of S-100B reflect the extent of brain injury in alcohol intoxicated patients after mild head trauma

Shock. 2001 Aug;16(2):97-101. doi: 10.1097/00024382-200116020-00002.


Elevated systemic levels of S-100B are proposed as a potential indicator of brain damage in identifying high-risk patients after mild head trauma (MHT). Although incidence of alcohol intoxication is high in these patients, the influence of alcohol intoxication on S-100B levels is unclear. Therefore, the aim of our study was to investigate serum concentrations of S-100B in intoxicated (group 1) and sober (group 2) patients after MHT in comparison with those of mild (group 3) or severely intoxicated (group 4) individuals without trauma. S-100B was significantly increased in MHT patients exhibiting posttraumatic lesions in initial cranial computed tomography scan. Alcohol intoxication did not elevate S-100B levels in group 3 or 4 subjects. Our data indicate for the first time that alcohol intoxication does not influence the diagnostic value of S-100B measurements in patients after MHT.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohol Drinking / blood
  • Alcoholic Intoxication / blood*
  • Alcoholic Intoxication / epidemiology
  • Biomarkers / blood
  • Brain Injuries / blood
  • Brain Injuries / diagnosis*
  • Craniocerebral Trauma / blood*
  • Disease Progression
  • Ethanol / blood*
  • Female
  • Humans
  • Immunoassay
  • Incidence
  • Luminescent Measurements
  • Male
  • Nerve Growth Factors
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins / blood*
  • Severity of Illness Index
  • Time Factors


  • Biomarkers
  • Nerve Growth Factors
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins
  • Ethanol