Findings on retinal topography and thickness mapping in age-related macular degeneration

Retina. 2001;21(4):352-60. doi: 10.1097/00006982-200108000-00010.


Purpose: To report alterations in the retinal topography and thickness in typical cases of age-related macular degeneration (ARMD).

Methods: An optical imaging system was applied to patients with ARMD with alterations in the retinal structures. The system generates a series of 20 optical section images that encompass a 2 mm x 2 mm retinal area. The optical sections are digitized and analyzed to provide topographic maps of the vitreo-retinal and chorio-retinal surfaces and the retinal thickness.

Results: Retinal topography and thickness mapping in a normal eye corresponded to normal anatomy. Topographic mapping in a patient with confluent drusen indicated elevation of the vitreo-retinal surface. Retinal topography in a patient with retinal pigment epithelium detachment displayed localized elevation of the chorio-retinal surface. The thickness map in a patient with geographic atrophy of the retinal pigment epithelium revealed retinal thinning. In the patients with choroidal neovascularization, the vitreoretinal and chorio-retinal surfaces were elevated. The chorio-retinal surface map in a patient with evolving disciform scar displayed topographic variations corresponding to the fibrovascular tissue underlying the serous detachment.

Conclusion: Retinal topography and thickness mapping is useful for visualization and evaluation of pathologic alterations in retinal structures due to ARMD.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Choroidal Neovascularization / diagnosis
  • Female
  • Fluorescein Angiography
  • Humans
  • Image Processing, Computer-Assisted
  • Macular Degeneration / diagnosis*
  • Male
  • Retina / pathology*
  • Retinal Drusen / diagnosis
  • Visual Acuity