Axoglial junctions: separate the channels or scramble the message

Curr Biol. 2001 Jul 24;11(14):R555-7. doi: 10.1016/s0960-9822(01)00341-4.


Axoglial junctions flank the nodes of Ranvier in myelinated nerves. These large cell adhesion complexes have an essential role in sequestering potassium channels located under the myelin sheath from nodal sodium channels. Recent studies have shed new light on the composition and function of axoglial junctions.

MeSH terms

  • Animals
  • Axons / physiology*
  • Intercellular Junctions / physiology*
  • Models, Neurological
  • Myelin Sheath / physiology
  • Neuroglia / physiology*
  • Potassium Channels / physiology
  • Ranvier's Nodes / physiology
  • Sodium Channels / physiology


  • Potassium Channels
  • Sodium Channels