Brain involvement in haemolytic-uraemic syndrome: MRI features of coagulative necrosis

Neuroradiology. 2001 Jul;43(7):581-5. doi: 10.1007/s002340100557.


We describe radiological demonstration of brain involvement in haemolytic-uraemic syndrome (HUS) in two siblings with a very different clinical course. While the brother presented with a mild, reversible encephalopathy, his sister developed high-signal lesions in the cortex, putamen and caudate nucleus on T1-weighted images, seen as dense areas on CT. Biopsy revealed coagulative necrosis due to microthrombosis without haemorrhage, calcification or infection. These findings suggest a possible prognostic role for MRI in cases of encephalopathy due to HUS.

Publication types

  • Case Reports

MeSH terms

  • Blood Coagulation Disorders / pathology*
  • Brain / blood supply
  • Brain / diagnostic imaging*
  • Brain / pathology*
  • Child, Preschool
  • Female
  • Hemolytic-Uremic Syndrome / diagnostic imaging
  • Hemolytic-Uremic Syndrome / pathology*
  • Humans
  • Infant
  • Intracranial Thrombosis / pathology
  • Magnetic Resonance Imaging*
  • Male
  • Necrosis
  • Radiography