Role of active oxygen species and antioxidants in photoaging

J Dermatol Sci. 2001 Aug;27 Suppl 1:S1-4. doi: 10.1016/s0923-1811(01)00120-7.

Abstract

The mechanism for the formation of active oxygen species and their reactions with antioxidants is described. The importance of the free radical chain oxidation and the singlet oxygen-dependent oxidation is suggested by a decrease in skin levels of alpha-tocopherol, ubiquinol-10, and ascorbic acid with a concomitant formation of lipid hydroperoxides during UV irradiation of murine skin, and the formation of squalene hydroperoxides in human skin upon UV exposure, respectively.

MeSH terms

  • Animals
  • Antioxidants / metabolism*
  • Ascorbic Acid / metabolism
  • Cholesterol Esters / metabolism
  • Free Radicals
  • Phosphatidylcholines / metabolism
  • Rats
  • Reactive Oxygen Species / metabolism*
  • Skin / metabolism
  • Skin / radiation effects*
  • Skin Aging / physiology*
  • Skin Aging / radiation effects*
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / metabolism
  • Ultraviolet Rays*
  • Vitamin E / metabolism

Substances

  • Antioxidants
  • Cholesterol Esters
  • Free Radicals
  • Phosphatidylcholines
  • Reactive Oxygen Species
  • phosphatidylcholine hydroperoxide
  • Ubiquinone
  • Vitamin E
  • cholesteryl ester hydroperoxide
  • ubiquinol-10
  • Ascorbic Acid