The adenomatous polyposis coli protein: in the limelight out at the edge

Trends Cell Biol. 2001 Sep;11(9):378-84. doi: 10.1016/s0962-8924(01)02069-4.

Abstract

Truncation mutations in the adenomatous polyposis coli protein (APC) are responsible for familial and sporadic colonic tumours. APC is best known for its role in regulating beta-catenin, an important mediator of cell adhesion and a transcriptional activator. However, recent studies indicate that APC has additional roles in cytoskeletal regulation. It binds to microtubules directly and indirectly. Furthermore, indirect connections between APC and the actin cytoskeleton have also been described. Here, we integrate recent information describing the association between APC and the cytoskeleton to illustrate how this multifaceted protein might link different cytoskeletal elements to each other and to cellular signaling pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenomatous Polyposis Coli Protein
  • Animals
  • Cytoskeletal Proteins / genetics
  • Cytoskeletal Proteins / metabolism*
  • Cytoskeleton / metabolism*
  • Genes, APC / physiology
  • Genes, Reporter
  • Humans
  • Microtubules / metabolism*
  • Models, Biological
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism
  • Protein Binding
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins / metabolism
  • Recombinant Fusion Proteins / genetics
  • Recombinant Fusion Proteins / metabolism
  • Signal Transduction / physiology
  • Wnt Proteins
  • Zebrafish Proteins*

Substances

  • Adenomatous Polyposis Coli Protein
  • Cytoskeletal Proteins
  • Neoplasm Proteins
  • Proto-Oncogene Proteins
  • Recombinant Fusion Proteins
  • Wnt Proteins
  • Zebrafish Proteins