Neuroactive steroid levels in patients with generalized anxiety disorder

T Semeniuk; G S Jhangri; J M Le Mellédo

doi:10.1176/jnp.13.3.396

Neuroactive steroid levels in patients with generalized anxiety disorder

J Neuropsychiatry Clin Neurosci. 2001 Summer;13(3):396-8. doi: 10.1176/jnp.13.3.396.

Authors

T Semeniuk¹, G S Jhangri, J M Le Mellédo

Affiliation

¹ Department of Psychiatry, University of Alberta Hospital, Edmonton, Alberta, Canada. tsemeniu@ualberta.ca

PMID: 11514647
DOI: 10.1176/jnp.13.3.396

Abstract

Serum levels of allopregnanolone, pregnenolone sulfate, and dehydroepiandrosterone sulfate were measured in 8 male patients with generalized anxiety disorder (GAD) and 8 healthy control subjects. Results suggest that patients with GAD have significantly lower levels of pregnenolone sulfate than control subjects.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Anxiety Disorders / metabolism*
Dehydroepiandrosterone / metabolism*
Female
Humans
Male
Pregnanolone / metabolism*
Pregnenolone / metabolism*
Receptors, GABA-A / metabolism*
gamma-Aminobutyric Acid / metabolism*

Substances

Receptors, GABA-A
pregnenolone sulfate
Dehydroepiandrosterone
gamma-Aminobutyric Acid
Pregnenolone
Pregnanolone