New adrenal-scanning agent

J Nucl Med. 1975 Jul;16(7):666-8.

Abstract

A new adrenal-specific compound, 6beta-iodomethyl-19-norcholest-5(10)-en-3beta-ol(NCL-3-I), which is derived from 19-iodocholesterol (CL-19-I), has been found. Tissue distribution studies have revealed that the rat adrenal gland accumulates ten times more NCL-6-131-I than CL-19-131-I. The advantage of NCL-6-131-I as a possible adrenal-scanning agent is discussed.

Publication types

  • Comparative Study

MeSH terms

  • Adrenal Gland Diseases / diagnosis*
  • Adrenal Glands / metabolism
  • Animals
  • Cholesterol / analogs & derivatives*
  • Cholesterol / blood
  • Cholesterol / metabolism
  • Iodine Radioisotopes
  • Kidney / metabolism
  • Liver / metabolism
  • Lung / metabolism
  • Male
  • Radionuclide Imaging*
  • Rats
  • Spleen / metabolism
  • Testis / metabolism
  • Thyroid Gland / metabolism

Substances

  • Iodine Radioisotopes
  • Cholesterol