Abstract
A new adrenal-specific compound, 6beta-iodomethyl-19-norcholest-5(10)-en-3beta-ol(NCL-3-I), which is derived from 19-iodocholesterol (CL-19-I), has been found. Tissue distribution studies have revealed that the rat adrenal gland accumulates ten times more NCL-6-131-I than CL-19-131-I. The advantage of NCL-6-131-I as a possible adrenal-scanning agent is discussed.
MeSH terms
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Adrenal Gland Diseases / diagnosis*
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Adrenal Glands / metabolism
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Animals
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Cholesterol / analogs & derivatives*
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Cholesterol / blood
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Cholesterol / metabolism
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Iodine Radioisotopes
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Kidney / metabolism
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Liver / metabolism
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Lung / metabolism
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Male
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Radionuclide Imaging*
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Rats
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Spleen / metabolism
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Testis / metabolism
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Thyroid Gland / metabolism
Substances
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Iodine Radioisotopes
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Cholesterol