Quantitative trait loci for body weight in the intercross between SM/J and A/J mice

Exp Anim. 2001 Jul;50(4):319-24. doi: 10.1538/expanim.50.319.


We performed a genome-wide quantitative trait locus (QTL) analysis of body weight at 10 weeks of age in a population of 321 intercross offspring from SM/J and A/J mice, progenitor strains of SMXA recombinant inbred strains. Interval mapping revealed two significant QTLs, Bwq3 (body weight QTL3) and Bwq4, on Chromosomes (Chrs) 8 and 18 respectively, and five suggestive QTLs on Chrs 2, 6, 7, 15 and 19. Bwq3 and Bwq4 explained 6% of the phenotypic variance. The SM/J alleles at both QTLs increased body weight, though the SM/J mouse was smaller than the A/J mouse. On the other hand, four of the five suggestive QTLs detected had male-specific effects on body weight and the remainder was female-specific. These suggestive QTLs explained 5-6% of the phenotypic variance and all the SM/J alleles decreased body weight.

MeSH terms

  • Alleles
  • Animals
  • Body Weight / genetics*
  • Chromosome Mapping*
  • Female
  • Genetic Markers
  • Genetic Variation*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Pedigree
  • Phenotype
  • Quantitative Trait, Heritable


  • Genetic Markers