A new method of 111In separation from a silver target irradiated with 30 MeV alpha-particles is described. The 111In isolation from Ag and Cd is based on its co-precipitation with La(OH)3. The 111In separation from La(III) has been performed by the method of ion-exchange chromatography. A multi-stage purification technique was developed that allows the production of 111In radiochemicals in which the part of impurities of di-, tri-valent metal atoms is negligible.