The resurgence of tuberculosis in Russia

Philos Trans R Soc Lond B Biol Sci. 2001 Jul 29;356(1411):1069-75. doi: 10.1098/rstb.2001.0895.


This paper documents and attempts to explain the epidemic spread of tuberculosis (TB) in Russia during the 1990s. After several decades of decline, the notification rate of all new TB cases among permanent residents increased by 7.5% per year from 1991-1999 and the death rate by 11% per year. Growth was quickest from 1993-1995 but increased again after the economic crisis of August 1998. Approximately 120 000 new cases and 30 000 deaths were reported in 1999. Case detection and cure rates have fallen in Russia since the mid-1980s; the fall has been accompanied by a higher frequency of severe disease among cases, and higher death and case fatality rates. With a mathematical model describing the deterioration in case finding and cure rates we could replicate the average rate of increase in incidence 1991-1999 but not the precise timing of the observed changes. Other factors that probably helped to shape the observed rise in caseload include enhanced transmission due to the mixing of prison and civilian populations, an increase in susceptibility to disease, and changes in the proportion of cases detected by surveillance. Although our explanation for the resurgence of TB is incomplete, we have identified a set of measures that can be implemented now to cut transmission, incidence and deaths.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Prevalence
  • Prisons
  • Quality of Health Care
  • Russia / epidemiology
  • Survival Rate
  • Treatment Outcome
  • Tuberculosis / drug therapy
  • Tuberculosis / epidemiology*