Motile organelles: the importance of specific tubulin isoforms

Curr Biol. 2001 Jun 5;11(11):R419-22. doi: 10.1016/s0960-9822(01)00250-0.

Abstract

The requirements for building flagellar axonemes and centrioles are beginning to be uncovered. The carboxyl terminus of a specific beta tubulin isoform plays an important role in forming the '9 + 2' structure of the axoneme; delta tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Centrioles / physiology*
  • Cilia / physiology*
  • Models, Structural
  • Molecular Motor Proteins / physiology
  • Molecular Sequence Data
  • Movement / physiology*
  • Organelles / physiology*
  • Protein Isoforms / metabolism
  • Tubulin / metabolism*

Substances

  • Molecular Motor Proteins
  • Protein Isoforms
  • Tubulin