Development of Tc-99m labeled tropanes: TRODAT-1, as a dopamine transporter imaging agent

Nucl Med Biol. 2001 Jul;28(5):505-8. doi: 10.1016/s0969-8051(01)00220-7.


Advances in the technetium chemistry have significantly enhanced the development of Tc-99m radiopharmaceuticals for clinical use. Efforts in designing novel Tc-99m labeled receptor or site-specific imaging agents using [Tc(v)O](+3)N(2)S(2) core have produced useful imaging agents for single photo emission computed tomography (SPECT). The success in developing Tc-99m TRODAT-1 for CNS dopamine transporters (DAT) serves as the first example of Tc-99m site-specific imaging of human brain. New innovative Tc-99m labeled site-specific agents are particularly suitable to develop simple and useful routine diagnostic procedures.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain Chemistry*
  • Dopamine Plasma Membrane Transport Proteins
  • Humans
  • Membrane Glycoproteins*
  • Membrane Transport Proteins / analysis*
  • Nerve Tissue Proteins*
  • Organotechnetium Compounds / metabolism
  • Radiopharmaceuticals*
  • Technetium*
  • Tomography, Emission-Computed
  • Tomography, Emission-Computed, Single-Photon
  • Tropanes / metabolism*


  • Dopamine Plasma Membrane Transport Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • SLC6A3 protein, human
  • Tropanes
  • technetium Tc 99m TRODAT-1
  • Technetium