Wnt Signalling: Antagonistic Dickkopfs

Curr Biol. 2001 Aug 7;11(15):R592-5. doi: 10.1016/s0960-9822(01)00360-8.

Abstract

Dickkopf proteins are secreted antagonists of the Wnt cell signalling molecules, which have a novel mode of action. Dickkopf1 binds to the LRP5/6 Wnt co-receptor and prevents the formation of active Wnt--Frizzled--LRP5/6 receptor complexes, thus blocking the canonical Wnt--beta-catenin pathway.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Frizzled Receptors
  • Humans
  • Intercellular Signaling Peptides and Proteins
  • LDL-Receptor Related Proteins
  • Low Density Lipoprotein Receptor-Related Protein-5
  • Protein Binding
  • Proteins / antagonists & inhibitors
  • Proteins / metabolism*
  • Proteins / physiology
  • Proto-Oncogene Proteins / antagonists & inhibitors
  • Proto-Oncogene Proteins / metabolism*
  • Receptors, LDL / antagonists & inhibitors
  • Receptors, LDL / metabolism
  • Signal Transduction*
  • Wnt Proteins
  • Zebrafish Proteins*

Substances

  • DKK1 protein, human
  • Frizzled Receptors
  • Intercellular Signaling Peptides and Proteins
  • LDL-Receptor Related Proteins
  • LRP5 protein, human
  • Low Density Lipoprotein Receptor-Related Protein-5
  • Proteins
  • Proto-Oncogene Proteins
  • Receptors, LDL
  • Wnt Proteins
  • Zebrafish Proteins
  • dkk1b protein, zebrafish