Abstract
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear receptor that is known to play a central role in adipocyte differentiation and insulin sensitivity. Through work in several animal models of intestinal inflammation, it is now recognized that PPARgamma also inhibits tissue injury associated with immune activation. These studies point to PPARgamma as a novel anti-inflammatory mediator with broad therapeutic potential.
Publication types
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News
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anti-Inflammatory Agents / metabolism
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Chromans / metabolism
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Colitis, Ulcerative / drug therapy*
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Colitis, Ulcerative / metabolism
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Crohn Disease / drug therapy*
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Crohn Disease / metabolism
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Disease Models, Animal
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Inflammation / metabolism
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Intestines / pathology
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Ligands
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Mice
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Receptors, Cytoplasmic and Nuclear / genetics
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Receptors, Cytoplasmic and Nuclear / metabolism*
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Rosiglitazone
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Thiazoles / metabolism
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Thiazolidinediones*
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Transcription Factors / genetics
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Transcription Factors / metabolism*
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Troglitazone
Substances
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Anti-Inflammatory Agents
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Chromans
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Ligands
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Receptors, Cytoplasmic and Nuclear
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Thiazoles
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Thiazolidinediones
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Transcription Factors
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Rosiglitazone
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Troglitazone