Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2001 Aug;7(4):386-90.
doi: 10.1080/13550280152537292.

Treatment of non-AIDS Progressive Multifocal Leukoencephalopathy With Cytosine Arabinoside

Clinical Trial

Treatment of non-AIDS Progressive Multifocal Leukoencephalopathy With Cytosine Arabinoside

A J Aksamit. J Neurovirol. .


This open label study determined the outcome of non-AIDS progressive multifocal leukoencephalopathy patients treated with a standard dose of intravenous cytosine arabinoside. Nineteen patients with PML proven by brain biopsy or spinal fluid polymerase chain reaction were treated with intravenous cytosine arabinoside 2 mg/kg per day for 5 days and followed for neurologic outcome by neurologic examination and MRI scanning. Seven of 19 PML patients treated with cytosine arabinoside intravenously improved neurologically. The range of follow-up for these patients was 2.0 to 4.5 years. All were left with neurologic deficits but were functionally improved, and 6 of 7 were able to independently carry out the activities of daily living. Twelve PML patients showed no evidence of response and died rapidly of their disease after treatment (range, 8 days to 6 months). All who survived their neurologic disease recovered from treatment-induced pancytopenia. Cytosine arabinoside given intravenously to non-AIDS PML patients in this small study was associated with a 36% chance of developing stabilization at 1 year. Treatment was associated with significant bone marrow toxicity. The improvement in MRI scan changes in those patients who responded took 6 weeks or longer.

Similar articles

See all similar articles

Cited by 20 articles

See all "Cited by" articles


    1. Ann Neurol. 1993 Apr;33(4):407-11 - PubMed
    1. Mayo Clin Proc. 1993 Sep;68(9):899-910 - PubMed
    1. Neurology. 1988 Jul;38(7):1060-5 - PubMed
    1. Lancet. 1992 Feb 1;339(8788):306 - PubMed
    1. J Neurol Neurosurg Psychiatry. 1975 Mar;38(3):205-9 - PubMed

Publication types

LinkOut - more resources