Substrate-induced polarisation of cultured epitheliocytes and fibroblasts: non-reactivity of Ras-transformed cells

Cell Biol Int. 2001;25(9):931-4. doi: 10.1006/cbir.2001.0776.

Abstract

Non-transformed epitheliocytes and fibroblasts undergo modulations between the less polarised and more polarised phenotypes depending on the nature of the substrate. In contrast, transformed cells express polarised phenotype regardless of the substrate.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Cell Line, Transformed
  • Cell Size
  • Cell Transformation, Neoplastic*
  • Collagen / pharmacology
  • Epithelial Cells / cytology*
  • Epithelial Cells / ultrastructure
  • Fibroblasts / cytology*
  • Fibroblasts / ultrastructure
  • Oncogene Protein p21(ras) / genetics*
  • Plastics / pharmacology
  • Polyhydroxyethyl Methacrylate / pharmacology
  • Rats
  • Stress Fibers / ultrastructure

Substances

  • Plastics
  • Polyhydroxyethyl Methacrylate
  • Collagen
  • Oncogene Protein p21(ras)