Biological evaluation of 2-fluoro-2-[123I]iodo-mannose (FIM): biological evaluation of FIM

Nucl Med Biol. 2001 Aug;28(6):679-82. doi: 10.1016/s0969-8051(01)00236-0.


This paper describes the biodistribution of a radio-iodinated analog of fluorodeoxyglucose (FDG). 123I-2-fluoro-2-iodo-mannose (FIM) was investigated as a potential single photon emission tomography (SPECT) imaging agent. We also compare the results with the observed distribution of the classical PET agent 18F-FDG and newly developed 18F-difluorodeoxyglucose (DFDG). Following radioiodination, the final product was stable in-vitro for 24 hrs. Mice showed a rapid blood clearance and deiodination of the 123I-FIM reflected by high stomach and thyroid uptake. Comparison with 18F-FDG and 18F-DFDG revealed a large discrepancy between the 18F labeled sugars and the 123I-FIM biological distribution. The iodinated product was not found to be a metabolic marker for in-vivo studies.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Fluorodeoxyglucose F18 / pharmacokinetics*
  • Iodine Radioisotopes
  • Mannose / analogs & derivatives
  • Mannose / pharmacokinetics*
  • Mice
  • Radiopharmaceuticals / pharmacokinetics*
  • Tissue Distribution


  • 2-fluoro-2-iodomannose
  • Iodine Radioisotopes
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • Mannose