The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins

J Clin Invest. 2001 Aug;108(4):511-6. doi: 10.1172/JCI13737.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylglucosamine / metabolism
  • Adult
  • Animals
  • Biopolymers
  • Bone Development / genetics
  • Bone Neoplasms / epidemiology
  • Bone Neoplasms / genetics
  • CHO Cells
  • Cartilage / pathology
  • Child
  • Cricetinae
  • DNA Mutational Analysis
  • Evolution, Molecular
  • Exostoses, Multiple Hereditary / genetics*
  • Genes, Dominant
  • Genes, Lethal
  • Genes, Tumor Suppressor*
  • Genetic Complementation Test
  • Genetic Predisposition to Disease
  • Glucuronic Acid / metabolism
  • Glycosylation
  • Heparitin Sulfate / biosynthesis
  • Heparitin Sulfate / physiology*
  • Humans
  • Invertebrates / growth & development
  • Invertebrates / metabolism
  • Macromolecular Substances
  • Mice
  • Mice, Knockout
  • Models, Biological
  • N-Acetylglucosaminyltransferases / deficiency
  • N-Acetylglucosaminyltransferases / genetics
  • N-Acetylglucosaminyltransferases / physiology*
  • Parathyroid Hormone-Related Protein
  • Proteins / genetics
  • Proteins / metabolism
  • Proteins / physiology*
  • Receptor, Parathyroid Hormone, Type 1
  • Receptors, Parathyroid Hormone / metabolism
  • Risk
  • Structure-Activity Relationship
  • Vertebrates / growth & development
  • Vertebrates / metabolism

Substances

  • Biopolymers
  • Macromolecular Substances
  • PTHLH protein, human
  • Parathyroid Hormone-Related Protein
  • Proteins
  • Receptor, Parathyroid Hormone, Type 1
  • Receptors, Parathyroid Hormone
  • Glucuronic Acid
  • Heparitin Sulfate
  • N-Acetylglucosaminyltransferases
  • exostosin-1
  • exostosin-2
  • Acetylglucosamine