TGF-beta/Smad signaling defects in inflammatory bowel disease: mechanisms and possible novel therapies for chronic inflammation

J Clin Invest. 2001 Aug;108(4):523-6. doi: 10.1172/JCI13863.
No abstract available

Publication types

  • Comment

MeSH terms

  • Chronic Disease
  • Cytokines / metabolism
  • DNA-Binding Proteins / antagonists & inhibitors
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Gene Expression Regulation
  • Humans
  • Immunosuppression
  • Inflammation / metabolism
  • Inflammation / therapy
  • Inflammatory Bowel Diseases / immunology
  • Inflammatory Bowel Diseases / metabolism*
  • Inflammatory Bowel Diseases / therapy
  • Intestinal Mucosa / immunology
  • Intestinal Mucosa / metabolism
  • Models, Biological
  • Receptors, Transforming Growth Factor beta / genetics
  • Receptors, Transforming Growth Factor beta / metabolism*
  • Signal Transduction*
  • Smad2 Protein
  • Smad3 Protein
  • Smad4 Protein
  • Smad7 Protein
  • Trans-Activators / antagonists & inhibitors
  • Trans-Activators / genetics
  • Trans-Activators / metabolism*
  • Transforming Growth Factor beta / metabolism*

Substances

  • Cytokines
  • DNA-Binding Proteins
  • Receptors, Transforming Growth Factor beta
  • SMAD2 protein, human
  • SMAD3 protein, human
  • SMAD4 protein, human
  • SMAD7 protein, human
  • Smad2 Protein
  • Smad3 Protein
  • Smad4 Protein
  • Smad7 Protein
  • Trans-Activators
  • Transforming Growth Factor beta