Partition coefficients and the structure-activity relationship of the anesthetic gases

J Med Chem. 1975 Jun;18(6):546-8. doi: 10.1021/jm00240a002.


Partition coefficients of 32 gaseous anesthetics in the octanol-water system have been determined. It is shown that relative anesthetic potency depends on hydrophobicity of the anesthetic (as defined by log P) and on a polar factor. The presence of a polar hydrogen in the anesthetic greatly increases potency. A quantitative structure-activity relationship is formulated based on these two factors.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anesthetics* / pharmacology
  • Animals
  • Kinetics
  • Mice
  • Octanols
  • Reflex / drug effects
  • Solubility
  • Structure-Activity Relationship
  • Water


  • Anesthetics
  • Octanols
  • Water