Dantaxusins A and B, two new taxoids from Taxus yunnanensis

J Nat Prod. 2001 Aug;64(8):1073-6. doi: 10.1021/np0100643.

Abstract

Two new taxane diterpenes, dantaxusin A [5 alpha-cinnamoyloxy-2 alpha,7 beta,13 alpha-triacetoxy-2(3-->20)abeo-taxa-4(20),11-diene-9,10-dione (1)] and dantaxusin B [5 alpha-cinnamoyloxy-9 alpha-hydroxy-10 beta,13 alpha-diacetoxytaxa-4(20),11-diene (2)], were isolated from an ethanol extract of the aerial parts of Taxus yunnanensis along with taxuspine B, 2-deacetoxytaxinine J, taxuyunnanine C, taxinine B, taxuspine C, and taxinine NN-4. The structures of 1 and 2 were established on the basis of 1D and 2D NMR and HRMS spectroscopic methods.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • China
  • Chromatography, High Pressure Liquid
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Paclitaxel / analogs & derivatives
  • Paclitaxel / chemistry
  • Paclitaxel / isolation & purification*
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Plants, Medicinal / chemistry*
  • Spectrophotometry, Ultraviolet
  • Stereoisomerism
  • Taxoids*

Substances

  • Taxoids
  • dantaxusin A
  • dantaxusin B
  • Paclitaxel