Spread of a multiresistant strain of Pseudomonas aeruginosa in an adult cystic fibrosis clinic

Lancet. 2001 Aug 18;358(9281):557-8. doi: 10.1016/s0140-6736(01)05714-2.


We initiated a prospective surveillance study to investigate possible Pseudomonas aeruginosa cross-infection in our cystic fibrosis centre. We characterised isolates by pyocin typing and pulsed-field gel electrophoresis. 22 (14%) of 154 patients with chronic P aeruginosa had isolates with similar and new pyocin and pulsed-field gel electrophoresis types. The shared isolates showed unusual phenotypic features: they were non-pigmented, non-motile, and resistant to a number of antipseudomonal antibiotics. Cross-infection by a multiresistant P aeruginosa strain has therefore occurred in patients attending our cystic fibrosis centre. We recommend microbiological surveillance in other cystic fibrosis centres.

Publication types

  • Letter

MeSH terms

  • Adult
  • Cross Infection / microbiology*
  • Cross Infection / transmission*
  • Cystic Fibrosis / microbiology*
  • DNA Fingerprinting
  • Drug Resistance, Microbial
  • Electrophoresis, Gel, Pulsed-Field
  • England / epidemiology
  • Female
  • Humans
  • Male
  • Phenotype
  • Population Surveillance
  • Prospective Studies
  • Pseudomonas Infections / transmission*
  • Pseudomonas aeruginosa / isolation & purification*
  • Pseudomonas aeruginosa / pathogenicity