Treatment of non-ulcer dyspepsia: a meta-analysis of placebo-controlled prospective studies

Scand J Gastroenterol. 2001 Sep;36(9):934-41. doi: 10.1080/003655201750305440.


Background: Dyspeptic symptoms are commonly reported complaints in clinical practice and are mostly the result of functional disorders. Empirical treatment with histamine H2-receptor blockers or gastroprokinetics for 2-4 weeks has frequently been proposed as first line management of these patients. The clinical trials which support the use of these agents, show a high variation in clinical success rate and benefit of these treatments.

Methods: The available clinical trials were evaluated, pooled where appropriate and subjected to a meta-analysis with the principal goal to provide valid treatment recommendations for patients with non-ulcer dyspepsia. In the present meta-analysis 19 studies on gastroprokinetics (cisapride, domperidone) and 10 studies on histamine H2-receptor antagonists (cimetidine, ranitidine) were included.

Results: Based on these studies, a total of 1540 patients were evaluated for histamine H2-receptor antagonists (verum n = 786, placebo n = 754) and 1235 patients for gastroprokinetics (verum n = 616, placebo n = 619). The probability for treatment success compared to placebo was 0.2026 (0.1261; 0.2791) for histamine H2-receptor antagonists and 0.4029 (0.3042; 0.5069) for gastroprokinetics.

Conclusions: Based on these data both treatments are significantly more effective than placebo in the symptomatic treatment of non-ulcer dyspepsia, with gastroprokinetics (cisapride, domperidone) being more effective than histamine H2-receptor antagonists (cimetidine, ranitidine).

Publication types

  • Meta-Analysis

MeSH terms

  • Cimetidine / therapeutic use
  • Cisapride / therapeutic use
  • Domperidone / therapeutic use
  • Dyspepsia / drug therapy*
  • Gastrointestinal Agents / therapeutic use*
  • Histamine H2 Antagonists / therapeutic use*
  • Humans
  • Ranitidine / therapeutic use
  • Research Design


  • Gastrointestinal Agents
  • Histamine H2 Antagonists
  • Domperidone
  • Cimetidine
  • Ranitidine
  • Cisapride