Genetic differences between adenocarcinomas arising in Barrett's esophagus and gastric mucosa

Gastroenterology. 2001 Sep;121(3):592-8. doi: 10.1053/gast.2001.27215.


Background & aims: Barrett adenocarcinoma (BA+) and gastric adenocarcinoma comprise a related group of neoplasms that nevertheless have some distinct clinicopathologic characteristics. This study aimed at defining critical molecular abnormalities that may underlie differences between BA+ and gastric adenocarcinomas.

Methods: We used comparative genomic hybridization for the analyses of 34 xenografts of adenocarcinomas that arose from esophageal or gastric origin.

Results: All tumors, except one, exhibited DNA copy number alterations. Losses in 4q and 14q and gains at 2p and 17q were more frequent in proximal (esophageal, gastroesophageal junction [GEJ], and cardia) tumors than in distal (body and antrum) tumors (P <or= 0.050). These changes were significantly higher in BA+ compared with distal tumors (P <or= 0.040). In addition, losses in 5q and gains at 20q were significantly higher in BA+ than in distal cancers (P <or= 0.040). Losses in 5q and 8p and gains at 2q, 6p, 12p, and 20q were significantly more frequent in BA+ tumors (P <or= 0.050) than in GEJ and cardiac tumors without associated Barrett's esophagus. Additionally, losses in 14q, which were common in proximal tumors, were more often seen in BA+ (P = 0.100) than in other proximal tumors.

Conclusions: Although these adenocarcinomas share some common genetic alterations, the differences in the DNA copy numbers in BA+ cases suggest that unique genetic alterations may be involved in these cancers' development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / genetics*
  • Adenocarcinoma / pathology
  • Animals
  • Barrett Esophagus / genetics*
  • Barrett Esophagus / pathology
  • Carcinoma, Signet Ring Cell / genetics
  • Carcinoma, Signet Ring Cell / pathology
  • Esophageal Neoplasms / genetics*
  • Esophageal Neoplasms / pathology
  • Gastric Mucosa / pathology
  • Gene Dosage
  • Humans
  • Immunocompromised Host
  • Mice
  • Mice, Mutant Strains
  • Neoplasm Transplantation
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / pathology
  • Transplantation, Heterologous