Protein stability: the COP9 signalosome gets in on the act

Curr Biol. 2001 Aug 21;11(16):R643-6. doi: 10.1016/s0960-9822(01)00382-7.

Abstract

The COP9 signalosome is a multiprotein complex somewhat similar to the lid component of the 26S proteasome. Recent studies suggest that it regulates the stability of proteins by interfering with the ubiquitin-proteasome pathway via deneddylation and phosphorylation.

MeSH terms

  • COP9 Signalosome Complex
  • Macromolecular Substances
  • Models, Biological
  • Multiprotein Complexes
  • Peptide Hydrolases
  • Phosphorylation
  • Plant Proteins / metabolism
  • Protein Subunits
  • Proteins / genetics
  • Proteins / metabolism*
  • Signal Transduction / physiology*
  • Ubiquitins / metabolism

Substances

  • Macromolecular Substances
  • Multiprotein Complexes
  • Plant Proteins
  • Protein Subunits
  • Proteins
  • Ubiquitins
  • Peptide Hydrolases
  • COP9 Signalosome Complex