Increased percentage of IL-12+ monocytes in the blood correlates with the presence of active MRI lesions in MS

J Neuroimmunol. 2001 Sep 3;119(1):145-9. doi: 10.1016/s0165-5728(01)00371-x.

Abstract

Interleukin (IL)-12 is a cytokine thought to play a major role in the pathogenesis of multiple sclerosis (MS). We have previously shown that patients with progressive MS have a high percentage of IL-12-producing monocytes in the blood compared to normal individuals. We analyzed 269 blood samples from 189 MS patients for the percentage of IL-12-producing monocytes. We found that the increased IL-12 expression correlates with disability, as measured by the Expanded Disability Status Scale (EDSS), and with disease activity, measured by the presence of gadolinium-enhancing magnetic resonance imaging (MRI) lesions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Female
  • Humans
  • Interleukin-12 / blood*
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Monocytes / metabolism*
  • Multiple Sclerosis / blood*
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / drug therapy
  • Multiple Sclerosis / physiopathology
  • Severity of Illness Index

Substances

  • Interleukin-12