PDZ proteins and polarity: functions from the fly

Trends Genet. 2001 Sep;17(9):511-9. doi: 10.1016/s0168-9525(01)02407-6.


Proteins that contain PDZ domains have been implicated in the localization of interacting partners to specific regions of the cell membrane. Although PDZ proteins that bind to a number of important mammalian proteins have been isolated, the significance of these interactions is unclear. In recent years, the fruit fly has emerged as a rich system for genetic analysis of PDZ protein function. Here, I discuss what the Drosophila data tell us about the roles and mechanisms of PDZ protein activity, and how this informs our understanding of PDZ function in other organisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Membrane / chemistry
  • Cell Membrane / genetics
  • Cell Polarity / genetics*
  • Cytogenetic Analysis
  • Drosophila / embryology*
  • Drosophila / genetics*
  • Drosophila / growth & development
  • Humans
  • Immunohistochemistry
  • Insect Proteins / chemistry*
  • Mutation
  • Protein Structure, Tertiary
  • Signal Transduction
  • Structure-Activity Relationship


  • Insect Proteins